Gero Miesenböck

Gero Miesenböck
Institutions University of Oxford
Alma mater University of Innsbruck
Known for optogenetics

Gero Miesenböck is Waynflete Professor of Physiology at the University of Oxford and a fellow of Magdalen College.[1] A native of Austria, he received his M.D. from the University of Innsbruck and undertook postdoctoral training with James Rothman.[2] Before coming to Oxford, he held faculty appointments at Memorial Sloan-Kettering Cancer Center[3] and Yale University.[4]

Miesenböck is the founder of the emerging field of optogenetics.[5][6] He has developed genetic strategies for visualizing and controlling nerve cells with light. He has invented several methods, including genetically targeted photostimulation of neurons and optical imaging of neurotransmission with synapto-pHluorin, a derivative of the green fluorescent protein.[7][8]

Miesenböck’s research on optogenetics and the nervous system of the fruit fly details the structure and function of neural circuits responsible for sensory processing, action selection, and motor pattern generation.

References

  1. ^ http://www.neuroscience.ox.ac.uk/directory/gero-miesenboeck Dr. Miesenböck’s Research Website at the University of Oxford
  2. ^ Miesenböck, G.; Rothman, J. (1995). "The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack". The Journal of cell biology 129 (2): 309–319. doi:10.1083/jcb.129.2.309. PMC 2199920. PMID 7721936. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199920.  edit
  3. ^ Zemelman, B. V.; Nesnas, N.; Lee, G.; Miesenbock, G. (2003). "Photochemical gating of heterologous ion channels: Remote control over genetically designated populations of neurons". Proceedings of the National Academy of Sciences 100 (3): 1352–1357. doi:10.1073/pnas.242738899. PMC 298776. PMID 12540832. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298776.  edit
  4. ^ Sjulson, L.; Miesenbock, G. (2008). "Rational Optimization and Imaging in Vivo of a Genetically Encoded Optical Voltage Reporter". Journal of Neuroscience 28 (21): 5582–5593. doi:10.1523/JNEUROSCI.0055-08.2008. PMC 2714581. PMID 18495892. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2714581.  edit
  5. ^ Miesenböck, G. (2009). "The Optogenetic Catechism". Science 326 (5951): 395–399. doi:10.1126/science.1174520. PMID 19833960.  edit
  6. ^ http://www.ted.com/talks/gero_miesenboeck.html Miesenböck speaks at TED about optogenetics
  7. ^ Wells, W. A. (2007). "Gero Miesenbock: Instructing the nervous system". The Journal of Cell Biology 177 (3): 374–375. doi:10.1083/jcb.1773pi. PMC 2064810. PMID 17485485. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2064810.  edit
  8. ^ http://www.nytimes.com/2005/04/12/science/12fly.html?ex=1188014400&en=c1ca4b6a117cc3f2&ei=5070 An off-and-on switch for controlling animals?